Top 5 Medications For Dog Hot Spots: Expert Buying Guide

Peter Armani | 11-02-2026

Hot spots can cause significant discomfort for dogs, leading to constant licking, scratching, and irritation. Choosing the right medication or topical treatment is essential for soothing your pet’s skin and supporting recovery. This guide compares various sprays, gels, and remedies designed for everyday use to help manage hot spots and minor skin issues in dogs.

Editor's Choice
Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray
Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray
Premium Pick
HICC PET Dog Wound Care Hydro Gel
HICC PET Dog Wound Care Hydro Gel
Budget Pick
PetArmor Hot Spot Skin Remedy
PetArmor Hot Spot Skin Remedy

Top 5 Medications For Dog Hot Spots

We researched and compared the top products in the Medications For Dog Hot Spots category to provide you with these recommendations.

1. Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray

Medicated Hot Spot Relief
Veterinary Formula Clinical Care Hot Spot & Itch Relief Medicated Spray
9.8

Veterinary Formula

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This spray has a lightweight, soothing feel and is often used for dogs and cats with irritated or itchy skin. Its non-greasy formula makes it easy to apply between baths, especially for pets prone to hot spots or compulsive licking. The practical spray bottle is suitable for quick touch-ups and daily management of minor skin discomfort.

What We Like:

  • Non-irritating, gentle formula
  • Can be used between washes
  • Adds moisture to coat
  • Suitable for both dogs and cats
  • Paraben and dye-free

What Could Be Improved:

  • Not for pets under 12 weeks
  • May require frequent reapplication

2. HICC PET Dog Wound Care Hydro Gel

Gentle Hydration Gel
HICC PET Dog Wound Care Hydro Gel
9.5

Hicc Pet

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This hydro gel feels cool and lightweight, making it comfortable for application on sensitive or inflamed skin. It's commonly used for soothing hot spots, minor wounds, and areas affected by rash or irritation. The gel forms a gentle barrier that helps keep skin hydrated while supporting the natural healing process.

What We Like:

  • Non-stinging, gentle formula
  • Hydrates and soothes irritated skin
  • Forms a protective film after application
  • Suitable for delicate areas like paws or folds
  • Easy to apply multiple times daily

What Could Be Improved:

  • May not adhere as well to very wet or heavily soiled skin

3. PetArmor Hot Spot Skin Remedy

Soothes Inflamed Skin
PetArmor Hot Spot Skin Remedy
9.5

Petarmor

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This liquid remedy is designed for direct application to hot spots, cuts, or abrasions. The formula is lightweight and dries quickly, making it practical for active dogs who may not tolerate thicker creams. It's commonly used as a first-aid option to calm irritation and support healing after minor skin injuries.

What We Like:

  • Quick-drying, non-greasy formula
  • Easy to apply to hard-to-reach areas
  • Can be used on minor wounds
  • Designed for dogs over six weeks old

What Could Be Improved:

  • May sting on open or raw skin
  • Requires supervision to prevent licking

4. Vetericyn Plus Hot Spot Spray for Dogs Skin Sores and Irritations

Hypochlorous Skin Relief
Vetericyn Plus Hot Spot Spray for Dogs Skin Sores and Irritations
8.7

Vetericyn

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This spray is designed for daily use on irritated or inflamed skin, providing a light mist that doesn't sting. It's often chosen for dogs with red, itchy patches, especially those prone to seasonal allergies. The formula is pH-balanced and non-toxic, making it safe if licked during grooming.

What We Like:

  • Non-stinging, gentle mist
  • pH-balanced for sensitive skin
  • Safe for frequent application
  • Suitable for dogs with allergy symptoms
  • Can be used on various skin irritations

What Could Be Improved:

  • May require consistent daily use
  • Not intended for deep or severe wounds

5. Restore + Soothe Hot Spot Spray

Gentle Skin Spray
Restore + Soothe Hot Spot Spray
9.1

Pet Honesty

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This spray features a light, refreshing scent and a gentle mist application, making it suitable for both dogs and cats. It's commonly used for soothing irritated skin, especially in pets sensitive to touch or with larger affected areas. The formula is free from harsh additives, offering a mild option for everyday relief.

What We Like:

  • Spray format covers wide areas easily
  • Pleasant lavender aroma
  • Alcohol- and sulfate-free
  • Safe for sensitive skin

What Could Be Improved:

  • Scent may not appeal to all pets
  • May require repeated use for best results

How to Choose Medications for Dog Hot Spots

Application Type: Spray, Gel, or Liquid

Choosing the right application type depends on your dog's temperament, the location of hot spots, and how often you'll need to reapply.

Sensitivity and Ingredients

Dogs with allergies or sensitive skin benefit from mild, fragrance-free, and pH-balanced products to minimize further irritation.

Frequency and Ease of Use

If your schedule is busy or your dog is active, a quick-absorbing spray or liquid may fit better than a gel that requires drying time.

Suitability for Wound Severity

Topical remedies are designed for mild to moderate skin issues. For deep, infected, or persistent wounds, consult your veterinarian before use.

Safety and Daily Management

If you have multiple pets or young animals, select a product with clear safety labeling for all intended users.

FAQ For Medications For Dog Hot Spots

1. What are hot spots on dogs?

Hot spots are localized areas of skin inflammation and infection that often appear as red, moist, and irritated patches. They can develop quickly due to scratching, licking, or underlying allergies.

2. How do I apply topical hot spot medication to my dog?

Clean the affected area as directed, then apply the medication according to package instructions. Prevent your dog from licking the area until the product has dried or absorbed.

3. Can I use these treatments on puppies?

Always check the age recommendations on the product label. Some formulations are not suitable for very young puppies, so consult your veterinarian if unsure.

4. How often should I reapply hot spot medication?

Reapplication frequency varies by product. Some require multiple daily uses, while others are intended for once-daily application. Follow the directions provided for best results.

5. When should I see a veterinarian for my dog's hot spots?

If the hot spot is spreading, not improving, or appears deep or infected, consult a veterinarian. Persistent or severe cases may require prescription medication or further diagnosis.
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Peter Armani

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