Best 5 Enzyme Detergents For Cat Urine You Can Buy

Peter Armani | 28-02-2026

Cat urine odors can be stubborn and persistent, especially on fabrics and household surfaces. Enzyme detergents are designed to break down organic compounds, making them a practical choice for tackling pet accidents. This guide compares several enzyme-based options for both laundry and spot cleaning, helping you find an effective solution for your home.

Editor's Choice
Nature’s Miracle Urine Destroyer Plus Cat
Nature’s Miracle Urine Destroyer Plus Cat
Premium Pick
ACTIVE Enzyme-Based Pet Laundry Detergent Powder
ACTIVE Enzyme-Based Pet Laundry Detergent Powder
Budget Pick
LaundraPet 3X Strength Premium Laundry Detergent with Enzyme Cleaner
LaundraPet 3X Strength Premium Laundry Detergent with Enzyme Cleaner

Top 5 Enzyme Detergents For Cat Urine

We researched and compared the top products in the Enzyme Detergents For Cat Urine category to provide you with these recommendations.

1. ACTIVE Enzyme-Based Pet Laundry Detergent Powder

Laundry Odor Removal
ACTIVE Enzyme-Based Pet Laundry Detergent Powder

This powder detergent feels concentrated and is often used for pet bedding, blankets, and clothing affected by urine odors. It's suitable for everyday laundry cycles and works with both pet-only and mixed loads. The fragrance-free formula is gentle on sensitive skin and doesn't cover up smells, but targets them directly.

What We Like:

  • Targets pet urine and tough odors
  • Works on many fabric types
  • Fragrance-free and gentle
  • Compatible with HE and standard washers
  • Can be used as a pre-soak

What Could Be Improved:

  • Powder may need extra dissolving in cold water
  • Pre-soaking required for heavy soiling

2. LaundraPet 3X Strength Premium Laundry Detergent with Enzyme Cleaner

Triple Enzyme Action
LaundraPet 3X Strength Premium Laundry Detergent with Enzyme Cleaner

This liquid detergent offers a concentrated feel and is formulated for pet-related laundry, including urine and heavy soils. It's often chosen for its compatibility with high-efficiency machines and its ability to handle larger loads. The enzyme-based formula is designed to break down organic stains and odors while being gentle on fabrics.

What We Like:

  • Triple enzyme cleaning power
  • Suitable for large or frequent loads
  • Works in cold water cycles
  • Gentle on most fabrics
  • Designed for pet-specific soils

What Could Be Improved:

  • Scent may be noticeable to sensitive pets
  • May require extra rinse for thick fabrics

3. Nature’s Miracle Urine Destroyer Plus Cat

Enzymatic Deep Cleaning
Nature’s Miracle Urine Destroyer Plus Cat
9.8

Nature's Miracle

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This spray feels lightweight and is easy to apply to carpets, floors, and fabrics. It's often used for cleaning up after accidents, as the enzymatic formula starts working on contact to break down urine compounds. The spray is suitable for use around pets and families, making it a practical option for quick, targeted odor removal.

What We Like:

  • Enzymatic action targets urine odors
  • Simple spray-and-blot application
  • Works on various surfaces
  • Safe for use around pets and children
  • Continues working as long as residue is present

What Could Be Improved:

  • May need repeat applications for older or set-in stains

4. Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder

Laundry Booster Powder
Enzyme Laundry Booster Odor Remover - 2 lbs Unscented Enzymatic Clothes Stain Cleaner Powder

This powder booster blends easily with your usual detergent and is designed for tackling stubborn odors and stains in laundry. It feels concentrated and is suitable for a variety of fabrics, including activewear and pet bedding. The unscented, plant-based formula is gentle and can be used in both standard and HE machines.

What We Like:

  • Enhances regular detergent performance
  • Focuses on strong odors and stains
  • Fragrance-free and plant-based
  • Suitable for whites, colors, and delicates
  • Can be used as a pre-soak

What Could Be Improved:

  • May require extra dissolving in cold water
  • Not a standalone detergent for very heavy soiling

5. Kinderbean Dog and Cat Laundry Wash, 32 oz. Enzyme Formula Pet Laundry Detergent Removes Pet Odors

Plant-Based Laundry Wash
Kinderbean Dog and Cat Laundry Wash, 32 oz. Enzyme Formula Pet Laundry Detergent Removes Pet Odors
8.7

Kinderbean

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This liquid laundry wash has a light, plant-based feel and is designed for use on pet bedding, blankets, and washable accessories. It's formulated with enzymes and probiotics to address tough pet stains and odors, including urine. The ready-to-use formula is simple to add to any wash cycle and is gentle enough for frequent use.

What We Like:

  • Plant-based and non-toxic ingredients
  • Targets a wide range of pet stains
  • Easy to use in regular or HE machines
  • Gentle on soft pet goods and fabrics
  • Lightly scented with natural extracts

What Could Be Improved:

  • Fragrance may not suit all preferences
  • May need repeat washes for set-in odors

How to Choose Enzyme Detergents for Cat Urine

Laundry vs. Surface Use

Laundry enzyme detergents are ideal for bedding, blankets, and clothing. Sprays or spot treatments are better for areas that can't go in the wash, like upholstery or floors.

Enzyme Strength and Formula

Stronger enzyme blends can help with persistent or older stains. Unscented formulas are less likely to irritate pets or people with sensitivities.

Compatibility with Washers and Fabrics

Always follow care labels on fabrics. For delicate materials, choose a gentle or plant-based detergent.

Application and Convenience

Consider your typical cleaning routine. If you need fast spot cleaning, a spray is practical. For regular laundry, a detergent or booster fits best.

Safety and Sensitivities

Pet-safe, gentle formulas are best for homes with sensitive animals or people. Always test a small area before full use.

FAQ For Enzyme Detergents For Cat Urine

1. How do enzyme detergents remove cat urine odors?

Enzyme detergents break down the organic compounds in cat urine, neutralizing the source of odor rather than just masking it. This process helps eliminate lingering smells from fabrics and surfaces.

2. Can enzyme detergents be used on all types of fabrics?

Most enzyme detergents are safe for a wide range of fabrics, but it's important to check the care label and the product's instructions. Delicate or specialty materials may require a gentler formula.

3. Are enzyme detergents safe for homes with pets and children?

Many enzyme detergents are formulated to be non-toxic and safe for use around pets and children. Always review the ingredient list and follow usage directions to ensure safety.

4. Do enzyme detergents work on old or set-in cat urine stains?

Enzyme detergents can help with old or set-in stains, but multiple applications or pre-soaking may be necessary for best results. Stubborn stains may require repeated treatment.

5. What is the difference between enzyme laundry detergents and enzyme sprays?

Enzyme laundry detergents are designed for use in washing machines to clean fabrics, while enzyme sprays are intended for spot cleaning on carpets, upholstery, or hard surfaces.
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Peter Armani

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