Top 5 Dog Heartworm Treatments: Best Picks

Peter Armani | 20-01-2026

Protecting your dog from heartworm and other internal parasites is a critical part of responsible pet care. With a range of treatments available, from monthly chewables to broad-spectrum dewormers, it can be challenging to choose the right option for your dog’s needs. This guide compares several widely used products and explains what to consider when selecting a heartworm preventive or dewormer.

Editor's Choice
PetArmor 7 Way De-Wormer for Large Dogs
PetArmor 7 Way De-Wormer for Large Dogs
Premium Pick
HEARTGARD Plus Real-Beef Chewables for Dogs up to 25 lbs
HEARTGARD Plus Real-Beef Chewables for Dogs up to 25 lbs
Budget Pick
PetArmor 7 Way De-Wormer for Small Dogs
PetArmor 7 Way De-Wormer for Small Dogs

Top 5 Dog Heartworm Treatments

We researched and compared the top products in the Dog Heartworm Treatments category to provide you with these recommendations.

1. PetArmor 7 Way De-Wormer for Large Dogs

Broad Spectrum Coverage
PetArmor 7 Way De-Wormer for Large Dogs
9.8

Petarmor

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This chewable option is designed for large dogs and offers a practical approach to managing several types of intestinal worms. The tablet has a firm texture that many dogs find acceptable, making it less stressful to administer. It’s intended for occasional use and can be easily integrated into a regular health routine for dogs over 25 pounds.

What We Like:

  • Targets multiple common worm species
  • Chewable format simplifies dosing
  • Suitable for a wide weight range
  • No prescription required
  • Clear usage instructions

What Could Be Improved:

  • Some dogs may dislike the taste
  • Not intended for puppies under 12 weeks

2. HEARTGARD Plus Real-Beef Chewables for Dogs up to 25 lbs

Monthly Heartworm Defense
HEARTGARD Plus Real-Beef Chewables for Dogs up to 25 lbs
9.5

Heartgard

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These chewable tablets are formulated for small dogs and offer a convenient way to help prevent heartworm disease. The real-beef flavor appeals to many dogs, making monthly dosing less of a struggle. Designed for regular use, they also address certain intestinal worms as part of a broader parasite control plan.

What We Like:

  • Vet-recommended preventive
  • Helps prevent heartworm disease
  • Also controls roundworms and hookworms
  • Palatable for many dogs
  • Simple monthly schedule

What Could Be Improved:

  • Prescription required
  • Not suitable for all weight ranges

3. PetArmor 7 Way De-Wormer for Small Dogs

Easy Chewable Tablets
PetArmor 7 Way De-Wormer for Small Dogs
9.5

Petarmor

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This chewable dewormer is formulated for small dogs and puppies, offering broad coverage against several types of intestinal worms. The tablets are sized for smaller breeds and are convenient to give as part of a routine health check. Many owners find the chewable format easy to use, especially for pets that resist pills.

What We Like:

  • Covers tapeworms, roundworms, and hookworms
  • Chewable design for easy administration
  • Suitable for dogs 6 to 25 pounds
  • Clear instructions included
  • No prescription needed

What Could Be Improved:

  • Some dogs may refuse the chew
  • Not for puppies under 12 weeks

4. PetArmor 7 Way De-Wormer for Large Dogs (Alternate)

Vet Quality Formula
PetArmor 7 Way De-Wormer for Large Dogs (Alternate)
9.1

Petarmor

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This broad-spectrum chewable is suitable for larger dogs and puppies over 12 weeks, addressing several common intestinal parasites. The chewable tablets are designed for straightforward dosing and can be given as part of a regular wellness routine. Many owners appreciate the convenience of the format for bigger breeds.

What We Like:

  • Treats multiple worm types
  • Chewable for easy use
  • For dogs 25.1 to 200 pounds
  • Instructions are clear and detailed

What Could Be Improved:

  • Some dogs may not accept the flavor
  • Not for very young puppies

5. Interceptor Plus Prevention for Heartworm + 4 Other Worms for Dogs 8.1-25 lbs

Multi Worm Protection
Interceptor Plus Prevention for Heartworm + 4 Other Worms for Dogs 8.1-25 lbs
8.7

Interceptor

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This monthly chewable provides protection against heartworm and several other common intestinal worms. The chicken-flavored tablet is designed to be palatable for most dogs, making regular administration easier. It’s intended for ongoing use and covers a wide range of parasites encountered in everyday environments.

What We Like:

  • Protects against heartworm and four other worms
  • Chicken flavor appeals to many dogs
  • Monthly dosing fits routine schedules
  • Covers parasites found in common dog areas

What Could Be Improved:

  • Prescription required
  • Only for dogs within a specific weight range

How to Choose Dog Heartworm Treatments

Choosing a heartworm treatment means balancing prevention, convenience, and your dog's lifestyle. Not all products target the same parasites, so it's important to match the treatment to your dog's specific needs.

Prescription vs. Non-Prescription Options

Prescription products are usually needed for heartworm prevention, while OTC options often focus on intestinal worms. Always confirm with your vet before starting any regimen.

Spectrum of Protection

Broader-spectrum products can simplify parasite control, but make sure the coverage matches your dog's risks and exposures.

Administration and Palatability

If your dog resists pills, a palatable chewable or flavored tablet can improve compliance. Consistency is key for effective prevention.

Weight and Age Suitability

Carefully match the product to your dog's current weight and age. Consult your vet if your dog is very young, old, or has health conditions.

Lifestyle and Regional Considerations

Your dog's environment and habits play a big role in choosing the right treatment. Adjust your approach if your dog's circumstances change.

FAQ For Dog Heartworm Treatments

1. What is the difference between a heartworm preventive and a dewormer?

Heartworm preventives protect against heartworm disease, which is transmitted by mosquitoes, while dewormers typically target intestinal parasites like roundworms, hookworms, and tapeworms. Some products offer both types of protection, but not all do.

2. How often should I give my dog heartworm medication?

Most heartworm preventives are given once a month, but always follow the product instructions and your veterinarian's recommendations for your dog's specific needs.

3. Can I use a dewormer instead of a heartworm preventive?

No, dewormers do not prevent heartworm disease. Heartworm prevention requires specific medications that target the heartworm parasite and should be used as directed by your veterinarian.

4. Do I need a prescription for heartworm prevention?

Most heartworm preventives require a prescription from a veterinarian, as a negative heartworm test is recommended before starting treatment. Some dewormers for intestinal parasites are available over the counter.

5. What should I do if my dog misses a heartworm dose?

If your dog misses a dose, give it as soon as you remember and consult your veterinarian for guidance. Missing doses can increase the risk of heartworm infection.
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Peter Armani

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