5 Best Detergent For Cat Pee: Buyer’s Guide

Peter Armani | 07-02-2026

Cat urine can be one of the toughest odors to remove from fabrics and home surfaces. Choosing the right detergent makes a big difference in eliminating smells and stains, whether you’re cleaning bedding, clothing, or carpets. This guide compares enzyme-based and pet-safe detergents designed to tackle cat pee, so you can find a solution that fits your cleaning routine and household needs.

Editor's Choice
Nature’s Miracle Urine Destroyer Plus Cat
Nature’s Miracle Urine Destroyer Plus Cat
Premium Pick
Nature's Miracle Urine Destroyer Plus for Cats, Unscented, Enzymatic Formula for Severe Cat Urine
Nature's Miracle Urine Destroyer Plus for Cats, Unscented, Enzymatic Formula for Severe Cat Urine
Budget Pick
ACTIVE Enzyme-Based Pet Laundry Detergent Powder
ACTIVE Enzyme-Based Pet Laundry Detergent Powder

Top 5 Detergent For Cat Pee

We researched and compared the top products in the Detergent For Cat Pee category to provide you with these recommendations.

1. ACTIVE Enzyme-Based Pet Laundry Detergent Powder

Laundry Odor Removal
ACTIVE Enzyme-Based Pet Laundry Detergent Powder

This powder detergent feels concentrated and is often used for pet bedding, blankets, and clothing affected by urine odors. It's suitable for everyday laundry cycles and works with both pet-only and mixed loads. The fragrance-free formula is gentle on sensitive skin and doesn't cover up smells, but targets them directly.

What We Like:

  • Targets pet urine and tough odors
  • Works on many fabric types
  • Fragrance-free and gentle
  • Compatible with HE and standard washers
  • Can be used as a pre-soak

What Could Be Improved:

  • Powder may need extra dissolving in cold water
  • Pre-soaking required for heavy soiling

2. LaundraPet 3X Strength Premium Laundry Detergent with Enzyme Cleaner

Triple Enzyme Action
LaundraPet 3X Strength Premium Laundry Detergent with Enzyme Cleaner

This liquid detergent offers a concentrated feel and is formulated for pet-related laundry, including urine and heavy soils. It's often chosen for its compatibility with high-efficiency machines and its ability to handle larger loads. The enzyme-based formula is designed to break down organic stains and odors while being gentle on fabrics.

What We Like:

  • Triple enzyme cleaning power
  • Suitable for large or frequent loads
  • Works in cold water cycles
  • Gentle on most fabrics
  • Designed for pet-specific soils

What Could Be Improved:

  • Scent may be noticeable to sensitive pets
  • May require extra rinse for thick fabrics

3. Nature's Miracle Urine Destroyer Plus for Cats, Unscented, Enzymatic Formula for Severe Cat Urine

Heavy Duty Odor Control
Nature's Miracle Urine Destroyer Plus for Cats, Unscented, Enzymatic Formula for Severe Cat Urine
9.1

Nature's Miracle

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This enzymatic formula is made for severe cat urine messes and is often used for both spot cleaning and refilling spray bottles. The unscented liquid works on contact and continues to break down urine compounds as long as residue is present. Its large bottle size makes it practical for frequent use in multi-cat homes or for restocking smaller containers.

What We Like:

  • Begins working immediately on stains
  • Suitable for refilling spray bottles
  • Enzymatic action continues as long as needed
  • Can be used on various surfaces
  • Intended for use around pets

What Could Be Improved:

  • Large size may be bulky to store
  • May require multiple applications for set-in stains

4. Nature’s Miracle Urine Destroyer Plus Cat

Enzymatic Deep Cleaning
Nature’s Miracle Urine Destroyer Plus Cat
9.8

Nature's Miracle

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This enzymatic spray is easy to use and designed for everyday messes on carpets, floors, and fabrics. It starts working on contact, making it a practical choice for quick clean-ups after accidents. The formula is intended for use around pets and families, offering a straightforward way to keep living spaces fresher.

What We Like:

  • Enzymatic action targets urine compounds
  • Simple spray-and-blot application
  • Designed for use on multiple surfaces
  • Can be used around pets and children
  • Works as long as residue remains

What Could Be Improved:

  • May require repeat use for older stains

5. Pet Parents PetTergent Enzymatic Pet Laundry Detergent

Pet-Safe Enzyme Formula
Pet Parents PetTergent Enzymatic Pet Laundry Detergent
8.7

Pet Parents

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This liquid detergent is formulated specifically for pet laundry, including dog blankets, toys, and beds. The enzyme blend targets pet stains and odors while using biodegradable, pet-safe ingredients. It's designed for regular use and aims to be gentle on both pet skin and noses.

What We Like:

  • Made for pet-specific stains
  • Uses biodegradable ingredients
  • Free from harsh chemicals
  • Safe for sensitive pet skin
  • Suitable for all laundry types

What Could Be Improved:

  • Scented formula may not suit all pets
  • May need pre-treatment for old stains

How to Choose Detergents for Cat Pee

Cat urine is notoriously difficult to remove. Enzyme-based detergents help break down the compounds that cause lingering odors and stains. Choose a product that matches your cleaning scenario—laundry or surface—and your household’s needs.

Laundry Detergents vs. Surface Cleaners

Laundry detergents are best for washable items, while surface cleaners are designed for spot-treating accidents on non-washable areas. Decide where most accidents occur before choosing.

Enzyme-Based Formulas

Enzyme cleaners are preferred for cat urine because they neutralize the source of the smell. Fragrance-free options are ideal for sensitive households.

Pet and Family Safety

Pet-safe detergents are important if your cat has allergies or sensitive skin. Check for ingredient transparency and avoid strong fragrances if your pet is sensitive.

Convenience and Use Case

Pick a format that matches your cleaning habits. Sprays are handy for immediate messes, while detergents are better for routine laundry.

Stain Age and Severity

Acting quickly helps prevent odors from setting. For older stains, plan on multiple treatments or longer soaking times.

FAQ For Detergent For Cat Pee

1. What type of detergent works best for cat urine odors?

Enzyme-based detergents are most effective because they break down the compounds in cat urine that cause persistent odors.

2. Can I use regular laundry detergent to remove cat pee?

Regular detergents may not fully eliminate cat urine odors or stains. Specialized enzyme-based products are designed to target and neutralize these issues.

3. Are enzyme detergents safe for pets and children?

Most enzyme detergents formulated for pet messes are designed to be safe for use around pets and children when used as directed. Always check the label for safety information.

4. Do I need to pre-soak fabrics affected by cat urine?

Pre-soaking can improve results, especially for older or heavily soiled items. Follow product instructions for best results.

5. Is it necessary to use a separate detergent for pet laundry?

Using a detergent made specifically for pet messes can improve odor and stain removal, but some people use it for all laundry to simplify cleaning routines.
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Peter Armani

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